As for bioanalysis applied to in vitro ADME, Bertin Pharma offers all its analytical expertise for this field.
For biologics such as therapeutic proteins, Bertin Pharma is able to assess their immunogenicity and the influence of the emergence of Anti-Drug Antibody (ADA) on PK parameters.
For bioanalytical step associated with ADA, testing process relies on three major steps: screening assays, confirmatory assays and neutralising assays (Enzyme-based & cell-based assays) followed by Routine analysis in Good Laboratory Practice (GLP).
Bertin Pharma has, in house, rodent animal models (mouse, rat, hamster, guinea-pig). For any other species, Bertin Pharma collaborates with partners.
Bertin Pharma has developed a specific expertise in Surgery in rodent for catheterization of jugular and portal vein & carotid and of choledoc, placement of gastric, intraduodenal, ileal, subcutaneous (Alzet® pump) and implant microdialyse implants. One possible application could be in-situ gastro-intestinal perfusion, sampling & analysis.
As of February 2011, the French Government has registered the Bertin Pharma Ethic Committee composed of 6 Bertin Pharma and independent people.
This commitment pursues the philosophy of Bertin Pharma with the use of Culex® in accordance with the Council Directive 2010/63/EU which aims to improve animal welfare by reducing their number and pain during experimentation.